Association between two unlinked loci at 8q24 and prostate cancer risk among European Americans.

  title={Association between two unlinked loci at 8q24 and prostate cancer risk among European Americans.},
  author={S{\'i}qun Lilly Zheng and Jielin Sun and Yu Cheng and Ge Li and Fang-Chi Hsu and Yi Zhu and Bao-li Chang and Wennuan Liu and Jin Woo Kim and Aubrey R. Turner and Marta Gielzak and Guifang Yan and Sarah D. Isaacs and Kathleen E. Wiley and Jurga Sauvageot and Huann-Sheng Chen and Robin T Gurganus and Leslie A. Mangold and Bruce J. Trock and Henrik Gronberg and David Duggan and John D. Carpten and Alan W. Partin and Patrick Walsh and Jianfeng Xu and William B Isaacs},
  journal={Journal of the National Cancer Institute},
  volume={99 20},
BACKGROUND Recent studies have provided evidence of associations between genetic markers at human chromosome 8q24 and an increased risk of prostate cancer. We examined whether multiple independent risk variants exist in this region and whether the strength of observed associations differs as a function of disease aggressiveness. METHODS We evaluated associations between 18 single-nucleotide polymorphisms (SNPs) in a 1-Mb interval at 8q24 and the risk of prostate cancer among 1563 case… CONTINUE READING


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Admixture mapping identifi es 8 q 24 as a prostate cancer risk locus in African - American men

  • ML Freedman, CA Haiman, N Patterson, GJ McDonald, A Tandon, A Waliszewska
  • Proc Natl Acad Sci USA
  • 2006

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