Association between tumor tissue TIMP-1 levels and objective response to first-line chemotherapy in metastatic breast cancer

Abstract

In a previous study from our laboratory, high tumor levels of tissue inhibitor of metalloproteinases-1 (TIMP-1) have been associated with an adverse response to chemotherapy in metastatic breast cancer suggesting that TIMP-1, which is known to inhibit apoptosis, may be a new predictive marker in this disease. The purpose of this study was to investigate the… (More)
DOI: 10.1007/s10549-009-0483-1

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