Association between tumor necrosis factor receptor II and familial, but not sporadic, rheumatoid arthritis: evidence for genetic heterogeneity.

@article{Dieud2002AssociationBT,
  title={Association between tumor necrosis factor receptor II and familial, but not sporadic, rheumatoid arthritis: evidence for genetic heterogeneity.},
  author={Philippe Dieud{\'e} and Elisabeth J. Petit and S{\'e}verine Cailleau-Moindrault and Jos{\'e} Francisco Sanz Osorio and C{\'e}line Pierlot and M Martinez and Sabine Faur{\'e} and Olivier Alibert and Sandra Lasbleiz and Claudia de Toma and Thomas Bardin and Bernard Prum and François Corn{\'e}lis},
  journal={Arthritis and rheumatism},
  year={2002},
  volume={46 8},
  pages={2039-44}
}
OBJECTIVE Tumor necrosis factor alpha (TNFalpha) binds the receptors TNFRI and TNFRII. Results of genome scans have suggested that TNFR2 is a candidate rheumatoid arthritis (RA) locus. A case-control study in a UK Caucasian population has shown an association between a TNFR2 genotype (196R/R in exon 6) and familial, but not sporadic, RA. The present study was undertaken to test this association in the French Caucasian population. METHODS To test for an association in sporadic RA, 100 families… CONTINUE READING
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