Association between tumor necrosis factor (TNF)-alpha G-308A gene polymorphism and preeclampsia complicated by severe fetal growth restriction.

@article{Molvarec2008AssociationBT,
  title={Association between tumor necrosis factor (TNF)-alpha G-308A gene polymorphism and preeclampsia complicated by severe fetal growth restriction.},
  author={Attila Molvarec and {\'A}gnes Jermendy and B{\'a}lint Nagy and Margit Kov{\'a}cs and Tibor V{\'a}rkonyi and Petronella Hupuczi and Zolt{\'a}n Proh{\'a}szka and J{\'a}nos Rig{\'o}},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2008},
  volume={392 1-2},
  pages={52-7}
}
BACKGROUND Preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome are multifactorial disorders with genetic and environmental components. Given that the tumor necrosis factor (TNF)-alpha G-308A single nucleotide polymorphism (SNP) affects TNF-alpha gene transcription and that preeclampsia and HELLP syndrome are characterized by a shift towards a Th1-type maternal immune response with increased TNF-alpha production, the aim of the current study was to… CONTINUE READING
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