Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study.

@article{Perlis2007AssociationBT,
  title={Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study.},
  author={Roy H. Perlis and Shaun M Purcell and Maurizio Fava and Jesen A. Fagerness and A. John Rush and Madhukar H. Trivedi and Jordan W. Smoller},
  journal={Archives of general psychiatry},
  year={2007},
  volume={64 6},
  pages={689-97}
}
CONTEXT A small subset of patients with depression exhibit new or worsening suicidal thoughts or behavior during short-term treatment with antidepressants. Because cyclic adenosine monophosphate response element binding (CREB) protein has been implicated in both antidepressant mechanisms and suicide, the CREB1 gene represents a gene that possibly influences the risk for treatment-emergent suicidality. OBJECTIVE To examine polymorphisms that span CREB1, which was previously associated with… CONTINUE READING
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