Association between the polymorphism A/G at position 49 of exon 1 of the CTLA-4 gene and antithyroid antibody production in children with Hashimoto's thyroiditis.

@article{Kucharska2012AssociationBT,
  title={Association between the polymorphism A/G at position 49 of exon 1 of the CTLA-4 gene and antithyroid antibody production in children with Hashimoto's thyroiditis.},
  author={Anna Małgorzata Kucharska and Alicja Wiśniewska and Katarzyna Popko and Urszula Demkow},
  journal={Hormone research in paediatrics},
  year={2012},
  volume={78 2},
  pages={67-72}
}
UNLABELLED CTLA-4 gene is considered to be one of the strongest factors determining the predisposition to antithyroid antibody (Ab) production. The aim of the study was to evaluate the association of the polymorphism A/G of exon 1 of CTLA-4 gene and antithyroid Ab level in children with Hashimoto's thyroiditis (HT). MATERIAL AND METHODS 45 children with HT (aged 14.9 ± 2, range 8.1-7.9) and 55 healthy controls (aged 14.8 ± 2.34, range 8.0-17.4) were enrolled. Controls were euthyroid and free… CONTINUE READING