Association between the methylation status of the MGMT promoter in bone marrow specimens and chemotherapy outcomes of patients with acute myeloid leukemia.

@article{Hong2016AssociationBT,
  title={Association between the methylation status of the MGMT promoter in bone marrow specimens and chemotherapy outcomes of patients with acute myeloid leukemia.},
  author={Qingxiao Hong and Xiaoying Chen and Huadan Ye and A. Ning Zhou and Yuting Gao and Danjie Jiang and Xiaodong Wu and Bingru Tian and Youfen Chen and Ming Wang and Jiping Xie and Yongming Xia and Shiwei Duan},
  journal={Oncology letters},
  year={2016},
  volume={11 4},
  pages={2851-2856}
}
The O(6)-methylguanine-DNA methyltransferase (MGMT) gene is a tumor suppressor gene that is associated with the risk of developing acute myeloid leukemia (AML). However, the association between the methylation status of the MGMT promoter and the chemotherapeutic outcomes of patients with AML remains unknown. In the present study, 30 bone marrow samples derived from patients with AML were collected prior and subsequent to chemotherapy. The methylation status of the MGMT promoter in the bone… CONTINUE READING