Association between the gamma-aminobutyric acid type B receptor 1 and 2 gene polymorphisms and mesial temporal lobe epilepsy in a Han Chinese population.

@article{Wang2008AssociationBT,
  title={Association between the gamma-aminobutyric acid type B receptor 1 and 2 gene polymorphisms and mesial temporal lobe epilepsy in a Han Chinese population.},
  author={Xin Wang and W. D. Sun and Xilin Zhu and Li-ping Li and Xiaopan Wu and Hua Lin and Shuying Zhu and Aihua Liu and Te Du and Yang Liu and Nifang Niu and Yu-Ping Wang and Ying Liu},
  journal={Epilepsy research},
  year={2008},
  volume={81 2-3},
  pages={198-203}
}
An abnormal gamma-aminobutyric acid B receptor composed of gamma-aminobutyric acid type B receptor 1 (GABBR1) and gamma-aminobutyric acid type B receptor 2 (GABBR2) can provoke seizures. This study was designed to assess the contribution of GABBR1 and GABBR2 in mesial temporal lobe epilepsy (MTLE). Two tag single-nucleotide polymorphisms (SNPs) of GABBR1 and four tag SNPs of GABBR2 were selected and genotyped in 318 MTLE patients and 315 non-epileptic individuals. The rs967932 A-allele of… CONTINUE READING