Association between the expression of inducible nitric oxide synthase by chondrocytes and its nitric oxide-generating activity in adjuvant arthritis in rats.

@article{Yonekura2003AssociationBT,
  title={Association between the expression of inducible nitric oxide synthase by chondrocytes and its nitric oxide-generating activity in adjuvant arthritis in rats.},
  author={Yukiko Yonekura and Ichiro Koshiishi and Ken-ichi Yamada and Akiko Mori and Soshi Uchida and Toshitaka Nakamura and Hideo Utsumi},
  journal={Nitric oxide : biology and chemistry},
  year={2003},
  volume={8 3},
  pages={164-9}
}
Inducible nitric oxide synthase (iNOS) is one of the clinical targets in rheumatoid arthritis. Synoviocytes, macrophages, and chondrocytes in the joints of patients with rheumatoid arthritis appear to express iNOS, but the contribution of iNOS molecules to rheumatoid arthritis is not yet clear. This study used adjuvant-induced arthritis in rats as a model to examine the association between the iNOS expression and its activity in rheumatoid arthritis. In adjuvant-injected rats, arthritic changes… CONTINUE READING
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