Association between the brain-derived neurotrophic factor Val66Met polymorphism and therapeutic response to olanzapine in schizophrenia patients

@article{Perkovi2014AssociationBT,
  title={Association between the brain-derived neurotrophic factor Val66Met polymorphism and therapeutic response to olanzapine in schizophrenia patients},
  author={Matea Nikolac Perkovi{\'c} and Gordana Nedic Erjavec and Maja Lj Živkovi{\'c} and Marina {\vS}agud and Suzana Uzun and Alma Mihaljevi{\'c}-Pele{\vs} and Oliver Kozumplik and Dorotea Muck-Seler and Nela Pivac},
  journal={Psychopharmacology},
  year={2014},
  volume={231},
  pages={3757-3764}
}
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays a major role in neurogenesis and neuroplasticity, and in the modulation of several neurotransmitter systems including the dopaminergic system. There are mixed reports about the association between the BDNF Val66Met polymorphism, schizophrenia, and treatment response to antipsychotic drugs. The present study evaluated the association of the BDNF Val66Met polymorphism with treatment response to atypical antipsychotic olanzapine… CONTINUE READING
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