Association between the V109G polymorphism of the p27 gene and the risk and progression of oral squamous cell carcinoma.

@article{Li2004AssociationBT,
  title={Association between the V109G polymorphism of the p27 gene and the risk and progression of oral squamous cell carcinoma.},
  author={Guojun Li and Erich M Sturgis and Lei Wang and R. M. Chamberlain and Margaret R. Spitz and A El-naggar and Waun Ki Hong and Qingyi Wei},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 12 Pt 1},
  pages={3996-4002}
}
PURPOSE Abnormalities in p27 may alter cell cycle delay required for DNA repair after exposure to carcinogens. A coding exon 1 polymorphism at codon 109 (T-->G) in p27 was identified and thought to have an effect on the functions of its protein. We hypothesized that this p27 T109G polymorphism is associated with squamous cell carcinoma of the head and neck (SCCHN) risk. EXPERIMENTAL DESIGN We tested this hypothesis in a hospital-based case-control study of 713 patients newly diagnosed with… CONTINUE READING