Association between the T-786C eNOS polymorphism and idiopathic osteonecrosis of the head of the femur.

@article{Glueck2007AssociationBT,
  title={Association between the T-786C eNOS polymorphism and idiopathic osteonecrosis of the head of the femur.},
  author={Charles J Glueck and Richard A. Freiberg and Jennifer Oghene and Robert N. Fontaine and Ping Wang},
  journal={The Journal of bone and joint surgery. American volume},
  year={2007},
  volume={89 11},
  pages={2460-8}
}
BACKGROUND Nitric oxide regulates bone turnover by osteoblasts and osteoclasts. Nitric oxide production is impaired by the T-786C eNOS single nucleotide polymorphism, with a substitution of the nucleotide thymine by cytosine at a locus 786 base pairs upstream of the eNOS gene. This leads to vasoconstriction, platelet aggregation, reduced angiogenesis, and reduced bone formation, all of which may be associated with osteonecrosis of the hip. We studied relationships between the T-786C eNOS… CONTINUE READING

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