Association between the PPARA L162V polymorphism and plasma lipid levels: the Framingham Offspring Study.

@article{Tai2002AssociationBT,
  title={Association between the PPARA L162V polymorphism and plasma lipid levels: the Framingham Offspring Study.},
  author={E. Shyong Tai and Serkalem Demissie and L. Adrienne Cupples and Dolores Corella and Peter W. F. Wilson and Ernst J. Schaefer and Jos{\'e} M. Ordov{\'a}s},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2002},
  volume={22 5},
  pages={805-10}
}
Peroxisome proliferator activated receptor (PPAR) alpha is a member of the nuclear receptor superfamily that regulates key proteins involved in fatty acid oxidation, extracellular lipid metabolism, hemostasis, and inflammation. A L162V polymorphism at the PPARA locus has been associated with alterations in lipid and apolipoprotein concentrations. We studied the association among lipids, lipoproteins, and apolipoproteins and the presence of the L162V polymorphism in 2373 participants (1128 men… CONTINUE READING