Association between the DRD2 A1 allele and response to methadone and buprenorphine maintenance treatments.

@article{Barratt2006AssociationBT,
  title={Association between the DRD2 A1 allele and response to methadone and buprenorphine maintenance treatments.},
  author={Daniel Thomas Barratt and Janet Kristie Coller and Andrew Alexander Somogyi},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2006},
  volume={141B 4},
  pages={323-31}
}
The TaqI A polymorphism (A(1)) of the dopamine D(2) receptor gene (DRD2), although not a specific predictor of opioid dependence, has been strongly associated with high levels of prior heroin use and poor treatment outcomes among methadone maintenance patients. The aims of this study were to confirm these findings via a retrospective analysis of A(1) allele frequency in methadone (n = 46) and buprenorphine (n = 25) patients, and non-opioid-dependent controls (n = 95). Subjects were genotyped at… CONTINUE READING

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