Association between the COMT Val158Met polymorphism and propensity to anxiety in an Australian population-based longitudinal study of adolescent health.

@article{Olsson2005AssociationBT,
  title={Association between the COMT Val158Met polymorphism and propensity to anxiety in an Australian population-based longitudinal study of adolescent health.},
  author={Craig A Olsson and Richard J. L. Anney and Mehrnoush Lotfi-Miri and Graham B. Byrnes and R. Williamson and George C. Patton},
  journal={Psychiatric genetics},
  year={2005},
  volume={15 2},
  pages={109-15}
}
OBJECTIVES Catechol-O-methyltransferase plays a central role in the metabolism of biogenic amines such as norepinephrine, dopamine and serotonin. Functional studies have demonstrated a dose relationship between ValMet genotypes and catechol-O-methyltransferase activity. Compared with the ValVal genotype, the ValMet and MetMet genotypes result in two- and four-fold reductions in catechol-O-methyltransferase activity, respectively. Two recent reports have observed the association between the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 53 extracted citations

Similar Papers

Loading similar papers…