Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample

@article{Pollex2007AssociationBT,
  title={Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample},
  author={Rebecca L. Pollex and Matthew R. Ban and Terence K. Young and Peter Bjerregaard and Sonia Savitri Anand and Salim Yusuf and Bernard Zinman and Stewart B Harris and Anthony J. G. Hanley and Philip W. Connelly and Murray W. Huff and Robert A Hegele},
  journal={BMC Medical Genetics},
  year={2007},
  volume={8},
  pages={80 - 80}
}
Common polymorphisms in the promoter of the APOC3 gene have been associated with hypertriglyceridemia and may impact on phenotypic expression of the metabolic syndrome (MetS). The rs7566605 marker, located near the INSIG2 gene, has been found to be associated with obesity, making it also a potential genetic determinant for MetS. The objective of this study is to examine the APOC3 -455T>C and the INSIG2 rs7566605 polymorphisms as potential genetic determinants for MetS in a multi-ethnic sample… CONTINUE READING