Association between telomere length in blood and mortality in people aged 60 years or older

@article{Cawthon2003AssociationBT,
  title={Association between telomere length in blood and mortality in people aged 60 years or older},
  author={Richard M. Cawthon and Ken R. Smith and Elizabeth O'Brien and Anna J. Sivatchenko and Richard A. Kerber},
  journal={The Lancet},
  year={2003},
  volume={361},
  pages={393-395}
}
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1,620 Citations
Highly Influential Citations
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564
Methods Citations
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1,620 Citations

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Association of shorter leukocyte telomere repeat length with dementia and mortality.
TLDR
The findings suggest that shortened leukocyte TL is associated with risks for dementia and mortality and may therefore be a marker of biological aging.
No Association Between Telomere Length and Survival Among the Elderly and Oldest Old
TLDR
This longitudinal study of the elderly and oldest old does not support the hypothesis that telomere length is a predictor for remaining lifespan once age is controlled for, and instead shows that among 175 twin pairs in which at least one died during follow up, it was the twin with the shorter telomerre length who died first.
Association between telomere length and heart disease in a narrow age cohort of older people
U-shaped relationship of leucocyte telomere length with all-cause and cancer-related mortality in older men.
  • B. Yeap, J. Hui, J. Beilby
  • Medicine, Biology
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2020
TLDR
In older men both shorter and longer LTL are associated with all-cause mortality, and a similar U-shaped association was seen with cancer deaths, with no association found for cardiovascular deaths.
The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people
The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men
TLDR
It is the first demonstration that rate of telomere length change (TLC) predicts mortality and thus may be a useful prognostic factor for longevity.
Telomere Length Among the Elderly and Oldest-Old
TLDR
A sex-specific difference in telomere length and shortening in individuals over the age span of 20 to 75 years is shown, and this difference may be caused by several different mechanisms, including differences in selection by mortality, differences in leukocyte population or different telomerase expression pattern.
Telomere length among the elderly and oldest-old.
TLDR
A sex-specific difference in telomere length and shortening in individuals over the age span of 20 to 75 years is shown, whereas the pattern tends to be nonlinear (quadratic in age) for males.
Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort study.
  • O. Njajou, W. Hsueh, R. Cawthon
  • Medicine, Biology
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2009
TLDR
The hypotheses that elderly persons with shorter TL in peripheral white blood cells have poorer survival, shorter life span, and fewer years of healthy life (YHL) are tested, suggesting that telomere length may be an informative biomarker of healthy aging.
The Association of Telomere Length with Colorectal Cancer Differs by the Age of Cancer Onset
TLDR
The findings indicate that the association of PBL telomeres length varies according to the age of cancer onset and that CRC is likely associated with at minimum two different mechanisms of telomere dynamics.
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References

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DNA markers and sampling of three-generation families can be used to construct complete linkage maps of human chromosomes. This is important in mapping disease loci and in determining the genetic or…