Association between telomere length and VH gene mutation status in chronic lymphocytic leukaemia: clinical and biological implications

@article{Hultdin2003AssociationBT,
  title={Association between telomere length and VH gene mutation status in chronic lymphocytic leukaemia: clinical and biological implications},
  author={Magnus Hultdin and Richard Rosenquist and Ulf Thunberg and Gerard Tobin and K F Norrback and Anna Johnson and Christer Sundstr{\"o}m and G{\"o}ran Roos},
  journal={British Journal of Cancer},
  year={2003},
  volume={88},
  pages={593 - 598}
}
The immunoglobulin VH gene mutation status can divide B-cell chronic lymphocytic leukaemia (CLL) into two entities with a different clinical course. Cases with unmutated VH genes, considered to evolve from pregerminal centre (GC) cells, have a worse outcome compared to cases showing mutated VH genes, that is, post-GC derived. Also, telomere length has been reported to be of prognostic significance in CLL. Interestingly, telomerase becomes activated during the GC reaction and an elongation of… CONTINUE READING

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Cd40 – Cd40l

  • S Weller, A Faili, +7 authors JC Weill
  • 2001
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