Association between telomerase activity and outcome in patients with nonmetastatic Ewing family of tumors.

@article{Ohali2003AssociationBT,
  title={Association between telomerase activity and outcome in patients with nonmetastatic Ewing family of tumors.},
  author={A. H. Ohali and Smadar Avigad and Ian Joseph Cohen and Isaac Meller and Yehuda Kollender and Josephine Issakov and Ilana Gelernter and Yacov Goshen and Isaac Yaniv and Rina Zaizov},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2003},
  volume={21 20},
  pages={
          3836-43
        }
}
PURPOSE Telomerase is considered a molecular marker for malignancy. The aim of this study was to determine telomerase activity (TA) as a prognostic factor at diagnosis and as a marker for minimal residual disease during therapy and follow-up in nonmetastatic Ewing family of tumors (EFT). PATIENTS AND METHODS Primary tumor specimens and 97 peripheral blood (PBL) samples from 31 EFT patients were analyzed for TA by the Telomeric Repeat Amplification Protocol (TRAP assay). The telomerase… CONTINUE READING

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