Association between single-nucleotide polymorphisms in pre-miRNAs and the risk of asthma in a Chinese population.

@article{Su2011AssociationBS,
  title={Association between single-nucleotide polymorphisms in pre-miRNAs and the risk of asthma in a Chinese population.},
  author={Xiao-wei Su and Yan Yang and Mei-Li Lv and Lijuan Li and Wenhua Dong and Miao-Liao and Lin-bo Gao and Hai-bo Luo and Yun-Liu and Rui-Juan Cong and Wei-bo Liang and Ying-bi Li},
  journal={DNA and cell biology},
  year={2011},
  volume={30 11},
  pages={919-23}
}
Single-nucleotide polymorphisms (SNPs) in pre-miRNAs may alter microRNA (miRNA) expression levels or processing and contribute to susceptibility to a wide range of diseases. We investigated the correlation between four SNPs (rs11614913, rs3746444, rs2910164, and rs229283) in pre-miRNAs and the risk of asthma in 220 asthma patients and 540 controls using polymerase chain reaction-restriction fragment length polymorphism methodology and DNA-sequencing. There were significant differences in the… CONTINUE READING

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