Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer.

@article{Pratesi2011AssociationBS,
  title={Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer.},
  author={Nicola Pratesi and Monica Mangoni and Irene Mancini and Fabiola Paiar and Lisa Simi and Lorenzo Livi and Sara Cassani and Michela Buglione and Salvatore Grisanti and Camillo Almici and Caterina Polli and Calogero Saieva and Stefano M. Magrini and Giampaolo Biti and Mario Pazzagli and C. James Orlando},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2011},
  volume={99 3},
  pages={356-61}
}
PURPOSE Individual variability in radiosensitivity is large in cancer patients. Single nucleotide polymorphisms (SNPs) in genes involved in DNA repair and in protection against reactive oxygen species (ROS) could be responsible for such cases of radiosensitivity. We investigated the association between the occurrence of acute reactions in 101 patients with squamous cell carcinoma of the head and neck (SCCHN) after radiotherapy (RT) and five genetic polymorphisms: XRCC1 c.1196A>G, XRCC3 c.722C>T… CONTINUE READING
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