Association between single nucleotide polymorphisms in the DNA repair gene LIG3 and acute adverse skin reactions following radiotherapy.

@article{Murray2011AssociationBS,
  title={Association between single nucleotide polymorphisms in the DNA repair gene LIG3 and acute adverse skin reactions following radiotherapy.},
  author={Robert J S Murray and George A. Tanteles and Jamie Mills and Angus Perry and Irene Peat and Ahmed E. Osman and Steve M Chan and Kwok Leung Cheung and Prabir Ranjan Chakraborti and Pamela L Woodings and Julian G Barwell and R. Paul Symonds and Christopher J. Talbot},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2011},
  volume={99 2},
  pages={231-4}
}
Many genes have been associated with radiotherapy toxicity, but most have only been found in a single study. Using our cohort of 480 breast cancer patients, we provide replicated evidence that a polymorphism near the LIG3 gene is associated with acute skin toxicity following radiotherapy. 

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