Association between schizophrenia and the syntaxin 1A gene.

  title={Association between schizophrenia and the syntaxin 1A gene.},
  author={Albert Hung Choy Wong and Joseph M. Trakalo and Olga Likhodi and Muneeb Yusuf and Ant{\^o}nio da Silva Mac{\^e}do and Maria-Helena Azevedo and Tim A Klempan and Michele T. Pato and William Honer and Carlos N. Pato and Hubert H M Van Tol and James L Kennedy},
  journal={Biological psychiatry},
  volume={56 1},
BACKGROUND Both microarray and candidate molecule studies have demonstrated that protein and mRNA expression of syntaxin and other genes involved in synaptic function are altered in the cerebral cortex of patients with schizophrenia. METHODS Genetic association between polymorphic markers in the syntaxin 1A gene and schizophrenia was assessed in a matched case-control sample of 192 pairs, and in an independent sample of 238 nuclear families. RESULTS In the family-based sample, a significant… CONTINUE READING