Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene

  title={Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene},
  author={European Cooperative Study Group and J. Williams and Gillian Spurlock and Peter McGuffin and M. J. Owen and J. Mallet and Markus M. N{\"o}then and Michael Gill and H. N. Aschauer and Peter O Nylander and Fabio Macciardi},
  journal={The Lancet},

Association between schizophrenia and DRD3 or HTR2 receptor gene variants

A significant association is clearly determined between the HTR2 genetic polymorphism and the presence of schizophrenic disorder, manifested as increased risk of schizophrenia for carriers of the T-102 allele.

T102C Polymorphisms at the 5-HT2A Receptor Gene in Turkish Schizophrenia Patients: A Possible Association with Prognosis

The findings indicate that the T102C polymorphisms of the 5-HT2A receptor gene does not play a substantial role in schizophrenia nor help evaluate susceptibility to schizophrenia.

Association study of serotonin 2A receptor (5-HT2A) and serotonin transporter (5-HTT) gene polymorphisms with schizophrenia

Association between T102C and A–1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: relevance for treatment with antipsychotic drugs

A higher frequency of 5-HTR2A –1438A and 102T alleles in SPs compared to HVs is demonstrated and no differences in genotype or allele frequencies were found between paranoid and non-paranoid SPs or between SPs on risperidone and those on classical antipsychotic treatment.

Susceptibility for schizophrenia is not influenced by a functional insertion/deletion variant in the promoter of the serotonin transporter gene

Allelic and genotypic variations of a recently described functional polymorphic region in the promoter of the human serotonin transporter gene (5-HTTLPR) and a variable tandem repeat (VNTR) in intron 2 of the 5-HTT gene indicate that both polymorphisms are unlikely to play a substantial role in the genetic predisposition to schizophrenic disorders.



Association versus linkage studies in psychosis genetics.

It is a major issue of current discussion to what extent association studies might complement the linkage approach in order to open the black box of psychosis genetics.

Association and linkage: complementary strategies for complex disorders.

Nothen et al argue persuasively for the use of association studies to identify the genetic defects responsible for the functional psychoses (schizophrenia and bipolar affective disorder) using anonymous markers and relying upon linkage disequilibrium.


  • B. Woolf
  • Mathematics
    Annals of human genetics
  • 1955
The use of x is recommended instead of d as a criterion of differential incidence of disease in relation to blood group, and in all statistical computations it is best to transform x into its logarithm.

The role of inheritance in behavior.

Genetic research on behavior will be transformed by techniques of molecular biology that can be used to identify DNA sequences responsible for behavioral variation, but the importance of nongenetic factors and the multigenetic control of behavior require new strategies to detect DNA markers that account for small amounts of behavioral variation.

A multicentre inter-rater reliability study using the OPCRIT computerized diagnostic system

The OPCRIT system, is both flexible and practicable retaining the 'top-down' advantage of operational definitions as well as the 'bottom-up' potential offered by well defined signs, symptoms and other component items.

A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system.

• An operational criteria checklist for psychotic illness and computer programs designed to be used in conjunction with it constitute the OPCRIT system. This provides a simple and reliable method of