Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene

@article{Group1996AssociationBS,
  title={Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene},
  author={European Cooperative Study Group and J. Williams and Gillian Spurlock and Peter McGuffin and M. J. Owen and J. Mallet and Markus M. N{\"o}then and Michael Gill and H. N. Aschauer and Peter O Nylander and Fabio Macciardi},
  journal={The Lancet},
  year={1996},
  volume={347},
  pages={1294-1296}
}

Association between schizophrenia and DRD3 or HTR2 receptor gene variants

TLDR
A significant association is clearly determined between the HTR2 genetic polymorphism and the presence of schizophrenic disorder, manifested as increased risk of schizophrenia for carriers of the T-102 allele.

T102C Polymorphisms at the 5-HT2A Receptor Gene in Turkish Schizophrenia Patients: A Possible Association with Prognosis

TLDR
The findings indicate that the T102C polymorphisms of the 5-HT2A receptor gene does not play a substantial role in schizophrenia nor help evaluate susceptibility to schizophrenia.

Association study of serotonin 2A receptor (5-HT2A) and serotonin transporter (5-HTT) gene polymorphisms with schizophrenia

Association between T102C and A–1438G polymorphisms in the serotonin receptor 2A (5-HT2A) gene and schizophrenia: relevance for treatment with antipsychotic drugs

TLDR
A higher frequency of 5-HTR2A –1438A and 102T alleles in SPs compared to HVs is demonstrated and no differences in genotype or allele frequencies were found between paranoid and non-paranoid SPs or between SPs on risperidone and those on classical antipsychotic treatment.

Susceptibility for schizophrenia is not influenced by a functional insertion/deletion variant in the promoter of the serotonin transporter gene

TLDR
Allelic and genotypic variations of a recently described functional polymorphic region in the promoter of the human serotonin transporter gene (5-HTTLPR) and a variable tandem repeat (VNTR) in intron 2 of the 5-HTT gene indicate that both polymorphisms are unlikely to play a substantial role in the genetic predisposition to schizophrenic disorders.
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