Association between risk of oral precancer and genetic variations in microRNA and related processing genes

@inproceedings{Roy2014AssociationBR,
  title={Association between risk of oral precancer and genetic variations in microRNA and related processing genes},
  author={Roshni Roy and Navonil De Sarkar and Sandip Ghose and Ranjan Rashmi Paul and Anindita Ray and Indranil Mukhopadhyay and Bidyut Kumar Roy},
  booktitle={Journal of Biomedical Science},
  year={2014}
}
MicroRNAs have been implicated in cancer but studies on their role in precancer, such as leukoplakia, are limited. Sequence variations at eight miRNA and four miRNA processing genes were studied in 452 healthy controls and 299 leukoplakia patients to estimate risk of disease. Genotyping by TaqMan assay followed by statistical analyses showed that variant genotypes at Gemin3 and mir-34b reduced risk of disease [OR = 0.5(0.3–0.9) and OR = 0.7(0.5–0.9) respectively] in overall patients as well as… CONTINUE READING
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