Association between protease inhibitor use and increased cardiovascular risk in patients infected with human immunodeficiency virus: a systematic review.

@article{Rhew2003AssociationBP,
  title={Association between protease inhibitor use and increased cardiovascular risk in patients infected with human immunodeficiency virus: a systematic review.},
  author={David C. Rhew and M Isabel Bernal and Daniel Aguilar and Uchenna H. Iloeje and Matthew Bidwell Goetz},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2003},
  volume={37 7},
  pages={
          959-72
        }
}
Some studies have shown that currently available protease inhibitors (PIs) are associated with an increased risk of cardiovascular disease. We have systematically reviewed the published literature and conference abstracts for studies evaluating cardiovascular risk factors and events in patients receiving highly active antiretroviral therapy, with and without PIs. The majority of studies showed that the use of PIs was associated with increased levels of total cholesterol (36 [75%] of 48 studies… CONTINUE READING

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