Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir

@article{Mallal2002AssociationBP,
  title={Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir},
  author={S. Mallal and D. Nolan and C. Witt and G. Masel and F. Christiansen},
  journal={The Lancet},
  year={2002},
  volume={359},
  pages={727-732}
}
  • S. Mallal, D. Nolan, +2 authors F. Christiansen
  • Published 2002
  • Biology, Medicine
  • The Lancet
  • BACKGROUND The use of abacavir--a potent HIV-1 nucleoside-analogue reverse-transcriptase inhibitor--is complicated by a potentially life-threatening hypersensitivity syndrome in about 5% of cases. Genetic factors influencing the immune response to abacavir might confer susceptibility. We aimed to find associations between MHC alleles and abacavir hypersensitivity in HIV-1-positive individuals treated with abacavir. METHODS MHC region typing was done in the first 200 Western Australian HIV… CONTINUE READING
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