Association between premature mortality and hypopituitarism

  title={Association between premature mortality and hypopituitarism},
  author={J W Tomlinson and N. Holden and R K Hills and Keith Wheatley and Rn Clayton and AS Bates and MC Sheppard and Pm Stewart},
  journal={The Lancet},
Deaths among adult patients with hypopituitarism: hypocortisolism during acute stress, and de novo malignant brain tumors contribute to an increased mortality.
Two important causes of excess mortality were identified: first, adrenal crisis in response to acute stress and intercurrent illness; second, increased risk of a late appearance of de novo malignant brain tumors in patients who previously received radiotherapy.
Mortality in adults with hypopituitarism: a systematic review and meta-analysis
Hypopituitarism may be associated with premature mortality in adults, and risk is particularly higher in women and those diagnosed at a younger age.
Hypopituitarism—needs modern individualized treatment
It is shown that GH replacement therapy is associated with normalized mortality among over 400 non-functioning pituitary adenoma patients receiving or not receiving GH replacement, who were followed for 10 years and suggested that there is a trend for higher mortality in patients without growth hormone (GH) replacement therapy.
Excess mortality associated with hypopituitarism in adults: a meta-analysis of observational studies.
Mortality benefit from GH replacement in hypopituitarism is less pronounced in women than men and there was a potential selection bias of benefit of GH replacement from a post-marketing data necessitating further evidence from long-term randomized controlled trials.
Overall and cause-specific mortality in GH-deficient adults on GH replacement.
OBJECTIVE Hypopituitarism is associated with an increased mortality rate but the reasons underlying this have not been fully elucidated. The purpose of this study was to evaluate mortality and
Excess Mortality Among Hospitalized Patients with Hypopituitarism - A Population Based Matched Cohort Study.
Patients with hypopituitarism are highly vulnerable once hospitalized for acute medical conditions with increased risk of mortality and adverse clinical outcomes, and this was most pronounced among those with diabetes insipidus.
Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population
Increased awareness of the other causes of pituitary dysfunction, such as congenital, head trauma, extrapituitary cranial irradiation, and infections, is the reason for a higher frequency of these etiologies of hypopituitarism in the presented database.
Life expectancy in patients with pituitary adenoma receiving growth hormone replacement.
OBJECTIVE Hypopituitarism has been associated with increased mortality. The excess mortality may be due to untreated growth hormone (GH) deficiency but also due to various underlying disorders. We
Direct causes of death in Japanese patients with hypopituitarism as analyzed from a nation-wide autopsy database.
The direct causes of death were investigated and compared between Japanese patients with hypopituitarism from a nation-wide autopsy database and an age- and gender-matched control population from national reports to provide useful information for the long-term care of Japanese patients in the frequency of death from ischemic heart disease.


The effect of hypopituitarism on life expectancy.
The data confirmed that mortality in patients with hypopituitarism is significantly increased, and the contribution of vascular disease to this poor prognosis was not as great as previously reported, and overall the results favor a multifactorial explanation of the poor long term outcome.
Mortality after the treatment of hyperthyroidism with radioactive iodine.
Mortality from all causes and mortality due to cardiovascular and cerebrovascular disease and fracture are increased among patients with hyperthyroidism treated withRadioiodine and the excess mortality was most evident in the first year after radioiodine therapy and declined thereafter.
Mortality and Cancer Incidence in Acromegaly: A Retrospective Cohort Study
Mortality rates due to colon cancer, all malignant disease, cardiovascular disease and overall mortality were increased with higher posttreatment GH leve...
An audit of outcome of treatment in acromegaly.
The present study suggests that the therapeutic objective should be to lower average daytime growth hormone levels to less than 5 mU/l, and calls for a large study to compare different modes of treatment in terms of their effect on growth hormone secretion and on long-term outcome.
Epidemiology and long-term survival in acromegaly. A study of 166 cases diagnosed between 1955 and 1984.
In 1985, a follow-up investigation was performed of all patients with acromegaly seen over a 30-year period at the Endocrine Unit, referral centre for the western region of Sweden, and the observed number of deaths from vascular and malignant disorders was 32 and 15, respectively, compared to the expected numbers.
Cardiovascular disease and risk factors in adults with hypopituitarism
The epidemiological and experimental data on cardiovascular morbidity and mortality in adult hypopituitarism and the prevalence of cardiovascular risk factors in this group of patients and their potential causes are reviewed.
The incidence of cerebrovascular accidents in patients with pituitary adenoma.
High incidence of cardiovascular disease and increased prevalence of cardiovascular risk factors in women with hypopituitarism not receiving growth hormone treatment: preliminary results.
Life expectancy following surgery for pituitary tumours
The aim of this study was to contribute further data to the debate regarding the putative association of vascular mortality with hypopituitarism.