Association between praziquantel and cholangiocarcinoma in patients infected with Opisthorchis viverrini: a systematic review and meta-analysis.

@article{KamsaArd2013AssociationBP,
  title={Association between praziquantel and cholangiocarcinoma in patients infected with Opisthorchis viverrini: a systematic review and meta-analysis.},
  author={Supot Kamsa-Ard and Malinee Laopaiboon and Vor Luvira and Vajarabhongsa Bhudhisawasdi},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  year={2013},
  volume={14 11},
  pages={
          7011-6
        }
}
BACKGROUND The liver fluke, Opisthorchis viverrini, and the associated incidence of subsequent cholangiocarcinoma (CCA) are still a public health problem in Thailand, and praziquantel (PZQ) remains the antihelminthic drug of choice for treatment. Evidence in hamsters shows that repeated infection and PZQ treatments could increase the risk of CCA. However, the existing evidence in humans is inconclusive regarding increased risk of CCA with frequency of PZQ intake. OBJECTIVES To investigate the… CONTINUE READING
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