Association between polymorphisms of the insulin-degrading enzyme gene and late-onset Alzheimer disease.

@article{Wang2015AssociationBP,
  title={Association between polymorphisms of the insulin-degrading enzyme gene and late-onset Alzheimer disease.},
  author={Shitao Wang and Feiyan He and Ying Wang},
  journal={Journal of geriatric psychiatry and neurology},
  year={2015},
  volume={28 2},
  pages={94-8}
}
The insulin-degrading enzyme (IDE) gene is a strong positional and biological candidate for late-onset Alzheimer disease (LOAD) susceptibility, with recent studies independently demonstrating an association between IDE gene variants and LOAD. However, previous data have been controversial. To investigate the relationship between IDE gene polymorphisms and LOAD risk, a case-control association study of 406 Han Chinese participants in Xinjiang, China, was undertaken. The LOAD and control groups… CONTINUE READING