• Corpus ID: 10336324

Association between polymorphisms of the DNA repair gene ( OGG 1 ) in Iraqi patients with type 2 diabetes mellitus

@inproceedings{Hassan2015AssociationBP,
  title={Association between polymorphisms of the DNA repair gene ( OGG 1 ) in Iraqi patients with type 2 diabetes mellitus},
  author={Bushra F. Hassan and NaghamEAl Essa and Nazar S. Shoky and Suha Nasser},
  year={2015}
}
Chronic hyperglycemia in type 2 diabetes mellitus leads to elevated oxidative stress . As a consequence , the accumulation of reactive oxygen species (ROS)may cause additional damage to various biological macromolecules, including DNA. Several studies have demonstrated that oxidative stress plays an important role in the pathogenesis of cardiovascular alterations observed in diabetic patients and that hyperglycemia is the causal link between diabetes and increased oxidative stress. Objectives… 

References

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This is the first study showing the association of a combined effect of GSTM1, T1 and P1 genotypes in a representative cohort of Indian patients with T2DM, and these polymorphisms can be screened in the population to determine the diabetic risk.

HOGG1 Ser326Cys polymorphism and modification by environmental factors of stomach cancer risk in Chinese

The findings suggest that the hOGG1 Ser326Cys polymorphism may alter the impact of some environmental factors on stomach cancer development, and an additional study with a larger number of subjects is now required.

Transcription Factors NF-YA Regulate the Induction of Human OGG1 Following DNA-alkylating Agent Methylmethane Sulfonate (MMS) Treatment*

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The function, antigenicity and survival of human islets exposed for 24 h to human pancreatic glucagon are evaluated.

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