Association between polymorphisms in the renin-angiotensin system genes and prevalence of spontaneously aborted fetuses.

@article{Jeon2013AssociationBP,
  title={Association between polymorphisms in the renin-angiotensin system genes and prevalence of spontaneously aborted fetuses.},
  author={Young Joo Jeon and Ji Hyang Kim and Bo Eun Lee and Hyungchul Rah and Ji Eun Shin and Hojeong Kang and Dong Hee Choi and Tae Ki Yoon and Woo Sik Lee and Sung Han Shim and Nam Keun Kim},
  journal={American journal of reproductive immunology},
  year={2013},
  volume={70 3},
  pages={238-45}
}
PROBLEM The renin-angiotensin system is associated with angiogenesis, tissue remodeling, prenatal development, and Th2 cytokine production. The purpose of this study was to evaluate whether polymorphisms in angiotensin I-converting enzyme [ACE insertion/deletion (I/D)], angiotensinogen (AGT M235T), and angiotensin II type 1 receptor (AT1R 1166A>C) affect the prevalence of spontaneously aborted fetuses (SAFs). METHOD OF STUDY One hundred and ninety-eight SAFs were <20 weeks of gestational age… CONTINUE READING