Association between polymorphisms in dopamine metabolic enzymes and tobacco consumption in smokers.

@article{McKinney2000AssociationBP,
  title={Association between polymorphisms in dopamine metabolic enzymes and tobacco consumption in smokers.},
  author={Eoin F. McKinney and Robert T Walton and Pat Yudkin and Anne M. Fuller and Neil A. Haldar and David Mant and Margaret Murphy and Kenneth Ian Welsh and Sarah E. Marshall},
  journal={Pharmacogenetics},
  year={2000},
  volume={10 6},
  pages={
          483-91
        }
}
Central dopaminergic reward pathways give rise to dependence and are activated by nicotine. Allelic variants in genes involved in dopamine metabolism may therefore influence the amount of tobacco consumed by smokers. We developed assays for polymorphisms in dopamine beta-hydroxylase (DBH), monoamine oxidase (MAO) and catechol O-methyl transferase (COMT) using the polymerase chain reaction with sequence specific primers (PCR-SSP). We then typed 225 cigarette smokers to assess whether genotype… CONTINUE READING

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