Association between polymorphism of tumour necrosis factor a308 gene promoter and asthma : a meta-analysis

Abstract

Background: Asthma is a complex polygenic disease in which gene–environment interactions are important. The gene encoding tumour necrosis factor alpha (TNFa) is one of several candidate loci for asthma pathogenesis and is highly polymorphic. A number of studies have investigated the polymorphism of TNFa-308 gene promoter (substitution GRA, designated as… (More)

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