Association between polymorphism in IgG Fc receptor IIIa coding gene and biological response to infliximab in Crohn's disease.

  title={Association between polymorphism in IgG Fc receptor IIIa coding gene and biological response to infliximab in Crohn's disease.},
  author={Edouard J. Louis and Zen El Ghoul and S{\'e}verine Vermeire and S{\'e}bastien Dall'Ozzo and P. R. Rutgeerts and Gilles Paintaud and Jacques Belaiche and M De Vos and Andr{\'e} van Gossum and J. -F. Colombel and Herv{\'e} Watier},
  journal={Alimentary pharmacology & therapeutics},
  volume={19 5},
AIM To test the hypothesis of an association between polymorphism in FCGR3A (the gene coding for FcgammaRIIIa, which is expressed on macrophages and natural killer cells, is involved in antibody-dependent cell-mediated cytotoxicity and has recently been associated with a positive response to rituximab, a recombinant immunoglobulin G1 antibody used in non-Hodgkin's lymphomas) and response to infliximab in Crohn's disease. METHODS FCGR3A-158 polymorphism was determined using an allele-specific… CONTINUE READING


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