Association between phosphorylated AMP-activated protein kinase and MAPK3/1 expression and prognosis for patients with gastric cancer.

@article{Kim2013AssociationBP,
  title={Association between phosphorylated AMP-activated protein kinase and MAPK3/1 expression and prognosis for patients with gastric cancer.},
  author={Jong Gwang Kim and Soo Jung Lee and Yee Soo Chae and Byung Woog Kang and You Jin Lee and Sung Yong Oh and Min Chan Kim and Ki Han Kim and Su-Jin Kim},
  journal={Oncology},
  year={2013},
  volume={85 2},
  pages={78-85}
}
OBJECTIVES Phosphorylated AMP-activated protein kinase (pAMPK) plays a central role in cellular metabolic sensing and energy balance homeostasis, and interacts with various pathways [e.g., TP53, mTOR, NUAK2 (sucrose nonfermenting-like kinase), MAPK3/1 (ERK) and PDK]. Therefore, the present study analyzed the expression of pAMPK, NUAK2, MAPK3/1 and PDK-1 and their effect on the survival of patients with resected gastric cancer. METHODS A total of 621 patients with gastric adenocarcinoma… CONTINUE READING