Association between parasite infection and immune responses in multiple sclerosis

@article{Correale2007AssociationBP,
  title={Association between parasite infection and immune responses in multiple sclerosis},
  author={Jorge Correale and Mauricio Franco Farez},
  journal={Annals of Neurology},
  year={2007},
  volume={61},
  url={https://api.semanticscholar.org/CorpusID:1033417}
}
To assess whether parasite infection is correlated with a reduced number of exacerbations and altered immune reactivity in multiple sclerosis (MS), a large number of patients with confirmed or suspected cases of multiple sclerosis are treated with a parasite infection.

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[Immunology of multiple sclerosis].

Investigations of the immunological status of multiple sclerosis patients have shown increases in some antiviral antibodies, a cytotoxic cellular response against central nervous system cells, and abnormal proportions of lymphocyte subpopulations in the peripheral blood.

Coincidence of immune‐mediated diseases driven by Th1 and Th 2 subsets suggests a common aetiology. A population‐based study using computerized General Practice data

This data indicates that suppression of T helper cells in the gut by a lack of microbial challenge, or dietary change, may have an adverse effect on the overall balance between mutually antagonistic subsets of Th cells.

Immunological modulation and evasion by helminth parasites in human populations

New techniques are starting to expose the diverse mechanisms by which these agents modulate or evade their hosts' defences, creating a dynamic interaction between the human immune system and the parasite population.

Schistosomiasis Decreases Central Nervous System Inflammation and Alters the Progression of Experimental Autoimmune Encephalomyelitis

It is suggested that schistosomiasis may negatively regulate the onset of EAE by downregulating the production of proinflammatory cytokines and altering CNS inflammation.

IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage.

Mechanisms that operate to regulate effector immune responses, which coordinately fight infections while preventing immune pathology, are discussed.

Autoimmune diseases: the failure of self tolerance.

The induction of autoimmunity involves genetic and environmental factors that have focused the attention of researchers on the trimolecular complex formed by major histocompatibility complex molecules, antigen, and T cell receptors, points to potential strategies for disease intervention.

A Novel Host-Parasite Lipid Cross-talk

Findings provide evidence for a novel host-parasite interaction that may be central to long term survival of the parasite and limited host pathology with implications beyond parasitology.

Helminth parasites – masters of regulation

It is hypothesized that parasites have evolved specific molecular strategies to induce this conducive landscape, and the foremost candidate immunomodulators released by helminths are reviewed, including cytokine homologs, protease inhibitors, and an intriguing set of novel products implicated in immune suppression.