Association between paraoxonase-1 gene polymorphisms and risk of metabolic syndrome

@article{KordiTamandani2011AssociationBP,
  title={Association between paraoxonase-1 gene polymorphisms and risk of metabolic syndrome},
  author={Dor Mohammad Kordi-Tamandani and Mohammad Hashemi and Nooshin Sharifi and Mahmoud Ali Kaykhaei and Adam Torkamanzehi},
  journal={Molecular Biology Reports},
  year={2011},
  volume={39},
  pages={937-943}
}
Paraoxonase-1 (PON1), a high-density lipoprotein (HDL) associated enzyme, is involved in the metabolism and detoxification of insecticides and pesticides. Three polymorphisms within the PON1 gene affect the enzyme activity. Two of these (L55M and Q192R) are located at the coding region and the third (–107C/T) is in promoter region. We performed a case–control study in order to elucidate the possible contribution of variability within PON1 at three mentioned positions to the risk of MS in a… CONTINUE READING

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