Association between p53 status, human papillomavirus infection, and overall survival in advanced oral cancer after resection and combination systemic treatment.

@article{Cutilli2016AssociationBP,
  title={Association between p53 status, human papillomavirus infection, and overall survival in advanced oral cancer after resection and combination systemic treatment.},
  author={Tommaso Cutilli and Pietro Leocata and Vincenza Dolo and Emma Altobelli},
  journal={The British journal of oral & maxillofacial surgery},
  year={2016},
  volume={54 2},
  pages={198-202}
}
Our previous study on 75 cases of advanced oral squamous cell carcinomas (SCC) treated by neoadjuvant chemotherapy, radical surgery, and radiotherapy showed that overexpression of p53 of more than 50% indicated a strong probability of genetic mutation, and tumours that are characterised by this p53 pattern respond poorly to treatment and have a poor prognosis (p= 0.0001). We have studied the same cohort of patients retrospectively to investigate the incidence of human papillomavirus-16 (HPV16… CONTINUE READING