Association between p53 and human papillomavirus in head and neck cancer survival.

@article{Smith2008AssociationBP,
  title={Association between p53 and human papillomavirus in head and neck cancer survival.},
  author={Elaine M. Smith and Donghong Wang and Linda M. Rubenstein and William A. Morris and Lubomir P. Turek and Thomas H. Haugen},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  year={2008},
  volume={17 2},
  pages={421-7}
}
BACKGROUND High-risk human papillomavirus (HPV-HR) is a significant risk factor for head and neck cancer (HNC), abrogating normal p53 function. In addition, HPV and p53 have been associated with prognosis of these tumors but the findings have been inconsistent. We examined p53 expression and HPV-HR individually and jointly for differences in predicting HNC survival. METHODS HNC patients (n = 294) were evaluated for p53 by immunohistochemical staining. HPV was detected by PCR/dot blot… CONTINUE READING