Association between osteonecrosis of the jaws and chronic high-dosage intravenous bisphosphonates therapy.

@article{Graziani2006AssociationBO,
  title={Association between osteonecrosis of the jaws and chronic high-dosage intravenous bisphosphonates therapy.},
  author={Filippo Graziani and Silvia Cei and Fabio La Ferla and Elisa Cerri and Angelo Itro and Mario Gabriele},
  journal={The Journal of craniofacial surgery},
  year={2006},
  volume={17 5},
  pages={876-9}
}
Bisphosphonates (BPs) are used to inhibit bone resorption. Recently, they have been used in cancer patients to prevent bone loss due to bone metastasis. Fourteen consecutive patients, undergoing BPs monthly IV infusion due to neoplastic bone diseases, were diagnosed with osteonecrosis of the jaws. None of the patients had been previously undergoing radiotherapy of the head and neck region. Eight patients showed maxillary involvement, and nine patients had had a recent tooth extraction in the… CONTINUE READING

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