Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis.

@article{Rizos2012AssociationBO,
  title={Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis.},
  author={Evangelos C. Rizos and Evangelia E. Ntzani and Eftychia Bika and M. Kostapanos and Moses S. Elisaf},
  journal={JAMA},
  year={2012},
  volume={308 10},
  pages={
          1024-33
        }
}
CONTEXT Considerable controversy exists regarding the association of omega-3 polyunsaturated fatty acids (PUFAs) and major cardiovascular end points. OBJECTIVE To assess the role of omega-3 supplementation on major cardiovascular outcomes. DATA SOURCES MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials through August 2012. STUDY SELECTION Randomized clinical trials evaluating the effect of omega-3 on all-cause mortality, cardiac death, sudden death, myocardial… 

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The evidence to date suggests that omega-3 fatty acids may result in a modest reduction in mortality and restenosis, however, caution must be exercised in interpreting these benefits as results were attenuated in higher quality studies, suggesting that bias may be at least partially responsible.
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Dietary supplementation with omega-3 fatty acids reduces the incidence of sudden cardiac death in patients with prior myocardial infarction, but may have adverse effects in angina patients.
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