Association between nonsyndromic cleft lip with or without cleft palate and the glutamic acid decarboxylase 67 gene in the Japanese population.

@article{Kanno2004AssociationBN,
  title={Association between nonsyndromic cleft lip with or without cleft palate and the glutamic acid decarboxylase 67 gene in the Japanese population.},
  author={Kiyoshi Kanno and Y. Suzuki and Atsushi Yamada and Yoko Aoki and Shigeo Kure and Yoichi Matsubara},
  journal={American journal of medical genetics. Part A},
  year={2004},
  volume={127A 1},
  pages={11-6}
}
Nonsyndromic cleft lip with or without cleft palate (NSCLP) is one of the most common craniofacial malformations. Both genetic and environmental factors are involved in the pathogenesis. In addition to its role as an inhibitory neurotransmitter, gamma-aminobutyric acid (GABA) synthesized by glutamic acid decarboxylase (GAD) is presumed to play a role in normal embryonic, especially facial, development. This notion has been substantiated by the fact that Gad67 knockout mice have been shown to… CONTINUE READING

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