Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies

@article{Aghajafari2013AssociationBM,
  title={Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies},
  author={Fariba Aghajafari and Tharsiya Nagulesapillai and Paul Everett Ronksley and Suzanne C Tough and Maeve O’Beirne and Doreen M. Rabi},
  journal={BMJ : British Medical Journal},
  year={2013},
  volume={346}
}
Objective To assess the effect of 25-hydroxyvitamin D (25-OHD) levels on pregnancy outcomes and birth variables. Design Systematic review and meta-analysis. Data sources Medline (1966 to August 2012), PubMed (2008 to August 2012), Embase (1980 to August 2012), CINAHL (1981 to August 2012), the Cochrane database of systematic reviews, and the Cochrane database of registered clinical trials. Study selection Studies reporting on the association between serum 25-OHD levels during pregnancy and the… 
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TLDR
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TLDR
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TLDR
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TLDR
Evidence is provided that the meta-analyses on the link between maternal vitamin D status and maternal / neonatal health consequences are characterized by a wide heterogeneity of studied populations as well as methodological pitfalls, including the absence of standardized vitamin D assays and evaluation of vital external regulators of vitamin D bio-networks.
Vitamin D and pregnancy outcomes
  • Shuqin Wei
  • Medicine
    Current opinion in obstetrics & gynecology
  • 2014
TLDR
An overview of the most recent scientific evidence of the role of maternal vitamin D on pregnancy outcomes is presented, with a particular emphasis on those articles in the English-language literature published between 1 January 2013 and 1 July 2014 in PubMed.
Maternal Vitamin D Status and Risk of Gestational Diabetes: a Meta-Analysis
TLDR
A meta-analysis of 29 observational studies showed that maternal vitamin D insufficiency was associated with a significantly increased risk of gestational diabetes, and subgroup analysis indicated that this association was also evident in most subpopulations.
Serum vitamin D status and in vitro fertilization outcomes: a systematic review and meta-analysis
TLDR
There is no significant correlation between deficient serum vitamin D level and lower clinical pregnancy rate in infertile woman undergoing in vitro fertilization, and on the other hand, deficient vitamin Dlevel was related to lower live birth rate.
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References

SHOWING 1-10 OF 57 REFERENCES
Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis.
TLDR
It is recommended that future research explore small-for-gestational age, preterm delivery, pre-eclampsia, and maternal and childhood infections, as outcomes of interest, and trials should focus on populations with a high prevalence of vitamin D deficiency.
Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women.
TLDR
The results suggest that vitamin D has a complex relation with fetal growth that may vary by race, and one SNP in the VDR gene among white women and 3 SNP in black women were significantly associated with SGA.
Maternal 25-hydroxyvitamin D and parathyroid hormone concentrations and offspring birth size.
TLDR
Low maternal 25-(OH)D in late pregnancy is associated with reduced intrauterine long bone growth and slightly shorter gestation and the positive relationship between maternal PTH and measures of infant size may relate to increased mineral demands by larger babies, but warrants further investigation.
Maternal vitamin D status during pregnancy and child outcomes
TLDR
Exposure to maternal concentrations of 25(OH)-vitamin D in pregnancy in excess of 75 nmol/l does not appear to influence the child's intelligence, psychological health or cardiovascular system; there could be an increased risk of atopic disorders, but this needs confirmation in other studies.
Maternal Plasma 25-Hydroxyvitamin D Concentrations and the Risk for Gestational Diabetes Mellitus
TLDR
Findings from the present study suggest that maternal vitamin D deficiency in early pregnancy is significantly associated with an elevated risk for gestational diabetes mellitus.
Maternal vitamin D deficiency increases the risk of preeclampsia.
TLDR
Maternal vitamin D deficiency may be an independent risk factor for preeclampsia and vitamin D supplementation in early pregnancy should be explored for preventing preeclampedia and promoting neonatal well-being.
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