Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies

  title={Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies},
  author={Fariba Aghajafari and Tharsiya Nagulesapillai and Paul Everett Ronksley and Suzanne C Tough and Maeve O’Beirne and Doreen M. Rabi},
  journal={BMJ : British Medical Journal},
Objective To assess the effect of 25-hydroxyvitamin D (25-OHD) levels on pregnancy outcomes and birth variables. Design Systematic review and meta-analysis. Data sources Medline (1966 to August 2012), PubMed (2008 to August 2012), Embase (1980 to August 2012), CINAHL (1981 to August 2012), the Cochrane database of systematic reviews, and the Cochrane database of registered clinical trials. Study selection Studies reporting on the association between serum 25-OHD levels during pregnancy and the… 
Association between maternal vitamin D levels and risk of adverse pregnancy outcomes: a systematic review and dose-response meta-analysis.
The meta-analysis provides further scientific evidence of the inverse association between 25(OH)D levels and the risk of GDM, PE, and GH, which may be useful for the prevention of pregnancy complications, but more evidence from prospective studies is needed regarding the dietary intake of vitamin D during pregnancy.
Association between maternal vitamin D deficiency and small for gestational age: evidence from a meta-analysis of prospective cohort studies
This meta-analysis suggests that vitamin D deficiency is associated with an increased risk of SGA, and subgroup analyses identified no significant differences in the association between Vitamin D deficiency and SGA based on study quality, gestational week, cut-off vitamin D levels, sample size, adjustment for critical confounders and method for measuring vitamin D.
Vitamin D status during pregnancy and offspring outcomes: a systematic review and meta-analysis of observational studies
Maternal vitamin D deficiency is associated with offspring adverse anthropometric outcomes and PTB; insufficiency with a higher risk of SGA, PTB and adverse neurodevelopmental outcomes.
Maternal vitamin D insufficiency and risk of adverse pregnancy and birth outcomes: A systematic review and meta-analysis of longitudinal studies
Vitamin D insufficiency was found to be associated with risk of PTB and the available evidence suggest no association with low vitamin D levels, and the benefits of vitamin D supplementation during pregnancy should be further evaluated through rigorous intervention studies.
Vitamin D and Pre-Eclampsia: Original Data, Systematic Review and Meta-Analysis
It is suggested that low maternal serum 25(OH)D concentrations increase pre-eclampsia risk and that vitamin D supplementation lowers this risk.
Maternal Vitamin D Deficiency and the Risk of Small for Gestational Age: A Meta-analysis
A meta-analysis of observational studies found that maternal vitamin D deficiency during pregnancy may be associated with an increased risk of SGA.
Maternal vitamin D status in pregnancy: a critical appraisal of current analytical data on maternal and neonatal outcomes
Evidence is provided that the meta-analyses on the link between maternal vitamin D status and maternal / neonatal health consequences are characterized by a wide heterogeneity of studied populations as well as methodological pitfalls, including the absence of standardized vitamin D assays and evaluation of vital external regulators of vitamin D bio-networks.
Vitamin D and pregnancy outcomes
  • Shuqin Wei
  • Medicine
    Current opinion in obstetrics & gynecology
  • 2014
An overview of the most recent scientific evidence of the role of maternal vitamin D on pregnancy outcomes is presented, with a particular emphasis on those articles in the English-language literature published between 1 January 2013 and 1 July 2014 in PubMed.
Maternal Vitamin D Status and Risk of Gestational Diabetes: a Meta-Analysis
A meta-analysis of 29 observational studies showed that maternal vitamin D insufficiency was associated with a significantly increased risk of gestational diabetes, and subgroup analysis indicated that this association was also evident in most subpopulations.
Serum vitamin D status and in vitro fertilization outcomes: a systematic review and meta-analysis
There is no significant correlation between deficient serum vitamin D level and lower clinical pregnancy rate in infertile woman undergoing in vitro fertilization, and on the other hand, deficient vitamin Dlevel was related to lower live birth rate.


Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis.
It is recommended that future research explore small-for-gestational age, preterm delivery, pre-eclampsia, and maternal and childhood infections, as outcomes of interest, and trials should focus on populations with a high prevalence of vitamin D deficiency.
Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women.
The results suggest that vitamin D has a complex relation with fetal growth that may vary by race, and one SNP in the VDR gene among white women and 3 SNP in black women were significantly associated with SGA.
Maternal 25-hydroxyvitamin D and parathyroid hormone concentrations and offspring birth size.
Low maternal 25-(OH)D in late pregnancy is associated with reduced intrauterine long bone growth and slightly shorter gestation and the positive relationship between maternal PTH and measures of infant size may relate to increased mineral demands by larger babies, but warrants further investigation.
Maternal vitamin D status during pregnancy and child outcomes
Exposure to maternal concentrations of 25(OH)-vitamin D in pregnancy in excess of 75 nmol/l does not appear to influence the child's intelligence, psychological health or cardiovascular system; there could be an increased risk of atopic disorders, but this needs confirmation in other studies.
Maternal Plasma 25-Hydroxyvitamin D Concentrations and the Risk for Gestational Diabetes Mellitus
Findings from the present study suggest that maternal vitamin D deficiency in early pregnancy is significantly associated with an elevated risk for gestational diabetes mellitus.
Maternal vitamin D deficiency increases the risk of preeclampsia.
Maternal vitamin D deficiency may be an independent risk factor for preeclampsia and vitamin D supplementation in early pregnancy should be explored for preventing preeclampedia and promoting neonatal well-being.