Association between macrophage activation and function of micro-encapsulated rat islets

@article{Vos2003AssociationBM,
  title={Association between macrophage activation and function of micro-encapsulated rat islets},
  author={Paul De Vos and I. Smedema and Harry van Goor and Henk Moes and Jacoba van Zanten and Sabine J Netters and Lou H. M. F. de Leij and Alex de Haan and Bart J. De Haan},
  journal={Diabetologia},
  year={2003},
  volume={46},
  pages={666-673}
}
Aims/hypothesis. Survival of microencapsulated islet grafts is limited, even when inflammatory reactions against the capsules are restricted to a small portion of less than 10%. Methods. This study investigates both in vivo in rat recipients and in vitro whether cellular overgrowth on this minority of the capsules contributes to limitations in the functional survival of the 90% of the encapsulated islets which remain free of any cellular overgrowth. Results. In successful rat recipients of an… CONTINUE READING

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