Association between mRNA expression of CD74 and IL10 and risk of ICU-acquired infections: a multicenter cohort study

  title={Association between mRNA expression of CD74 and IL10 and risk of ICU-acquired infections: a multicenter cohort study},
  author={Estelle Peronnet and Fabienne Venet and Delphine Maucort-Boulch and Arnaud Friggeri and Martin Cour and Laurent Argaud and Bernard Allaouchiche and Bernard Floccard and Fr{\'e}d{\'e}ric Aubrun and Thomas R. Rimmele and Fabrice Thiolli{\`e}re and Vincent Piriou and Julien Boh{\'e} and Marie-Angelique Cazalis and V{\'e}ronique Barbalat and Guillaume Monneret and St{\'e}phane Morisset and Julien Textoris and H{\'e}l{\`e}ne Vallin and Alexandre Pachot and Alain Lepape},
  booktitle={Intensive Care Medicine},
Intensive care unit (ICU)-acquired infections (IAI) result in increased hospital and ICU stay, costs and mortality. To date, no biomarker has shown sufficient evidence and ease of application in clinical routine for the identification of patients at risk of IAI. We evaluated the association of the systemic mRNA expression of two host response biomarkers, CD74 and IL10, with IAI occurrence in a large cohort of ICU patients. ICU patients were prospectively enrolled in a multicenter cohort study… CONTINUE READING
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