Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene, O6-alkylguanine-DNA alkyltransferase.

@article{Crosbie2008AssociationBL,
  title={Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene, O6-alkylguanine-DNA alkyltransferase.},
  author={Phil A Crosbie and Gail McGown and Mary R Thorncroft and Paul N S O'Donnell and Philip V Barber and Sarah Jayne Lewis and Kathryn L Harrison and Raymond M. Agius and Mauro F. Santibanez-Koref and G. P. Margison and Andrew C. Povey},
  journal={International journal of cancer},
  year={2008},
  volume={122 4},
  pages={791-5}
}
The association between lung cancer risk and 2 polymorphisms, rs12268840 and rs2308327 (codon K178R), in the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase, which are associated with interindividual differences in activity, have been investigated in 3 hospital-based case-control studies. Genotyping was carried out on 617 subjects of whom 255 had lung cancer. In 2 of the 3 series, there was a significant inverse association between the 178R allele and case status (p < 0.05). In a… CONTINUE READING