Association between low activity serotonin transporter promoter genotype and early onset alcoholism with habitual impulsive violent behavior

@article{Hallikainen1999AssociationBL,
  title={Association between low activity serotonin transporter promoter genotype and early onset alcoholism with habitual impulsive violent behavior},
  author={Tero Hallikainen and Takuya Saito and Herbert M. Lachman and J. V. Volavka and Tiina Pohjalainen and Olli-Pekka Ryyn{\"a}nen and Jussi Kauhanen and Erkka Syv{\"a}lahti and Jarmo Hietala and Jari Tiihonen},
  journal={Molecular Psychiatry},
  year={1999},
  volume={4},
  pages={385-388}
}
A common 44-base pair insertion/deletion polymorphism in the promoter region of the human serotonin transporter (5-HTT) gene has been observed to be associated with affective illness and anxiety-related traits. This biallelic functional polymorphism, designated long (L) and short (S), affects 5-HTT gene expression since the S promoter is less active than the L promoter. Since there is strong evidence of a disturbance in brain serotonergic transmission among antisocial, impulsive, and violent… CONTINUE READING

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