Association between leptin, obesity, hormonal interplay and male infertility

@article{Amjad2019AssociationBL,
  title={Association between leptin, obesity, hormonal interplay and male infertility},
  author={Sofia Amjad and Mukhtiar Baig and Nida Zahid and Sundus Tariq and Rehana Rehman},
  journal={Andrologia},
  year={2019},
  volume={51}
}
Male infertility is a major health problem worldwide. We investigated a possible association between leptin, obesity, hormonal interplay and male infertility. This cross‐sectional study of 313 males (178 infertile and 135 fertile) was carried out in 2017. The subjects were categorised by body mass index (BMI) and body fat percentage (BF%) into normal weight, overweight and obese. Significantly higher levels of BMI and BF% (p‐value < 0.001) and lower levels of FSH, LH, testosterone, and SHBG (p… Expand
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References

SHOWING 1-10 OF 40 REFERENCES
Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohort
TLDR
Hyperinsulinaemia and hyperleptinaemia are associated with increased seminal insulin and leptin concentrations, which may negatively impact male reproductive function in obesity, and insulin was also found to be highly concentrated in the seminal plasma of both groups. Expand
Relation of Serum Leptin with sex Hormones of obese Infertile Men and Women
TLDR
Serum leptin has strong negative correlation with LH, FSH and testosterone in fertile obese and normal male and female which were statistically significant at the level of p<0.05. Expand
Serum leptin levels in obese infertile men and women.
TLDR
It is concluded that obesity is associated with infertility in men and women and sex hormonal imbalance may also be associated BMI and serum leptin in infertility. Expand
Comparison of Serum Leptin Level in Women with Unexplained Infertility and Fertile Women in Iran
TLDR
No statistically significant relationship was found between serum leptin levels in the two groups and there were no significant relationships between leptin and other predisposing factors such as hormone profile and antral follicle count. Expand
Semen parameters and hormonal profile in obese fertile and infertile males.
TLDR
Serum leptin mediates a link between obesity and male infertility and demonstrates significant positive correlation with patients' age, abnormal sperm morphology, serum FSH, LH, PRL and significant negative correlation with sperm concentration, sperm motility, and serum T. Expand
Evidence for Alteration in Serum Concentrations of Leptin in Infertile Men Categorized Based on BMI.
TLDR
The findings of this study support this concept that increased BMI is of clinical relevance in the context of infertility in men since the data revealed an inverse correlation between seminal leptin level and BMI in infertile men. Expand
Mechanisms linking obesity to male infertility
  • A. Katib
  • Medicine
  • Central European journal of urology
  • 2015
TLDR
The prime hormonal defect in obese men is hypotestosteronaemia, which results in impaired spermatogenesis leading to poor fecundability, and a new, detailed flow chart is presented showing more factors and further interactions among conditions leading to infertility. Expand
Obesity and male infertility
TLDR
Several interdependent mechanisms contribute to the detrimental effect of obesity on male fertility, and large, randomized control trials are needed to better characterize the therapeutic benefits of weight loss to restore male reproductive potential. Expand
Impact of male obesity on infertility: a critical review of the current literature.
TLDR
The increasing prevalence of obesity calls for greater clinician awareness of its effects on fertility, better understanding of underlying mechanisms, and eventually avenues for mitigation or treatment. Expand
Markers of accessory glands and seminal parameters in infertile men with overweight and obesity
TLDR
Obesity has a negative impact on sperm quality and prostatic function, although sperm parameters changes are more evident in men with morbid obesity, so it may expect infertility, prostate pathologies could be avoided if hyperadiposity in infertile men is controlled opportunely. Expand
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