Association between large-scale genomic homozygosity without chromosomal loss and nonseminomatous germ cell tumor development.

@article{Lu2005AssociationBL,
  title={Association between large-scale genomic homozygosity without chromosomal loss and nonseminomatous germ cell tumor development.},
  author={Yong-Jie Lu and Jinshu Yang and Elodie E Noel and Spyros Skoulakis and Tracy Chaplin and Manoj Raghavan and Trisha Purkis and Alan H McIntyre and Sakunthala C. Kudahetti and Mahmoud Naase and Daniel Berney and Janet Shipley and R Timothy D Oliver and Bryan D. Young},
  journal={Cancer research},
  year={2005},
  volume={65 20},
  pages={9137-41}
}
The genotype of a tumor determines its biology and clinical behavior. The genetic alterations associated with the unique embryonal morphology of nonseminomatous subtypes of testicular germ cell tumors remain to be established. Using single nucleotide polymorphism microarray analysis, we found in all of the 15 nonseminomas analyzed, large-scale chromosomal homozygosities, most of which were not associated with relative chromosome loss. This unusual genotype, distinguishing nonseminoma from… CONTINUE READING